TELIK ANNOUNCES INTERIM PHASE 1-2A TELINTRA™ CLINICAL DATA IN RESISTANT MYELODYSPLASTIC SYNDROME TO BE PRESENTED AT AMERICAN SOCIETY OF HEMATOLOGY MEETING

Palo Alto, CA, December 3, 2003 — Telik, Inc. (Nasdaq: TELK) announced that it will present positive interim results from the Phase 1-2a clinical trial of TELINTRA™ (TLK199) in patients with myelodysplastic syndrome at the American Society of Hematology annual meeting.

The presentation, “Hematologic Improvement Following Treatment with TLK199 (a Novel Glutathione Analog Inhibitor of GST P1-1) in Myelodysplastic Syndrome: Interim Results of a Phase 1-2a Study”,will take place on Saturday, December 6, 2003 in San Diego, California.

About Telik, Inc.

Telik, Inc. of Palo Alto, CA is a biopharmaceutical company working to discover, develop and commercialize small molecule drugs to treat serious diseases for which there is significant demand for new therapies. The company’s most advanced drug development candidate is TELCYTA™. Telik's product candidates were discovered using its proprietary technology, TRAP, which enables the rapid and efficient discovery of small molecule drug candidates. Additional information is available at www.telik.com.

You should not rely on forward-looking statements contained in this press release, including statements regarding our ability to successfully develop TELINTRA™ for MDS or any other condition, its tolerability, potential efficacy or market potential. Telik can give no assurance with regard to these statements. None of our products have been determined to be safe or effective in humans or been approved for marketing. Substantial additional testing will be necessary prior to seeking marketing approval. There can be no assurance that such trials will accrue sufficient patients, be conducted with sufficient quality, in a timely manner, have a successful outcome, or that regulatory approval will be obtained. In addition, we are reliant on external manufacturing, and any interruption or delay in drug supply could adversely affect the development program. More detailed information regarding factors that may cause actual results to differ materially from the results expressed or implied by statements in this press release may be found in Telik's periodic filings with the Securities and Exchange Commission. Telik assumes no obligation to update any information in this press release.

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Contact:
Carol DeGuzman
Senior Director, Corporate Communications
Telik, Inc.
Tel 650-845-7728
Email cdeguzman@telik.com


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