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Palo Alto, CA, August 14, 2003 — Telik, Inc. (Nasdaq:
TELK) reported positive follow-up data from a Phase 2 clinical trial
of TELCYTA™ (TLK286) in patients with non-small cell lung
cancer whose disease progressed following platinum-containing regimens.
The data were reported at the Tenth World Conference on Lung Cancer
in Vancouver, British Columbia.
Patients enrolled in this trial received TELCYTA™ as second-
or third-line treatment for advanced non-small cell lung cancer.
An 11% objective response rate was observed in the 19 patients evaluable
for efficacy at the time of analysis. The overall disease stabilization
rate was 69%. Median survival has not yet been reached. TELCYTA™
continues to be well tolerated, with the most common adverse events
categorized as Grade 1 or 2 (mild to moderate).
“These maturing results further confirm the clinical activity
of TELCYTA™ that has been reported in non-small cell lung
cancer, including earlier data from this trial presented at the
American Society of Clinical Oncology meeting in June, and data
from a previous Phase 2 trial in non-small cell lung cancer,”
said Gail L. Brown, M.D., senior vice president and chief medical
officer. “We look forward to the initiation of the TELCYTA™
Phase 3 registration trial in non-small cell lung cancer later this
year.”
In Phase 2 trials, TELCYTA™ has demonstrated clinical activity
in ovarian, breast and colorectal cancer, in addition to non-small
cell lung cancer. A high proportion of these tumors express GST P1-1, which activates TELCYTA™ within the tumor. A Phase 3
registration trial of TELCYTA™ in women with advanced ovarian
cancer is in progress, in addition to ongoing trials evaluating
TELCYTA™ in combination with standard chemotherapies.
About Non-Small Cell Lung Cancer and TELCYTA™
Lung cancer results in 28% of all cancer deaths in the U.S., and
it is the leading cause of cancer deaths, according to the American
Cancer Society (ACS). The ACS estimates that 171,900 new cases of
lung cancer, most of the non-small cell type, will be diagnosed
in 2003, and an estimated 157,200 deaths will result from the disease.
TELCYTA™ is a small molecule prodrug which is activated by
GST P1-1, an enzyme present in higher levels in many human cancers
than in normal tissues. Upon activation, an intracellular process
known as apoptosis, or programmed cell death, is initiated. TELCYTA™,
which has been evaluated in clinical trials in more than 400 patients,
was discovered through the application of Telik’s proprietary
drug discovery technology, TRAP. Telik has retained worldwide commercialization
rights.
About Telik, Inc.
Telik, Inc. of Palo Alto, CA is a biopharmaceutical company working
to discover, develop and commercialize small molecule drugs to treat
serious diseases for which there is significant demand for new therapies.
The company’s most advanced drug development candidate is
TELCYTA™, in a Phase 3 registration trial in advanced ovarian
cancer, and in earlier stage clinical trials in ovarian, non-small
cell lung and breast cancer. Telik’s product candidates were
discovered using its proprietary technology, TRAP, which enables
the rapid and efficient discovery of small molecule drug candidates.
Additional information is available at www.telik.com.
You should not rely on forward-looking statements contained in
this press release, including statements regarding our ability to
successfully develop TELCYTA™ for the treatment of any cancer,
its tolerability, potential efficacy or market potential. Telik
can give no assurance with regard to these statements. None of our
products have been determined to be safe or effective in humans
or been approved for marketing. Substantial additional testing,
including randomized, controlled clinical trials of TELCYTA™
will be necessary prior to seeking marketing approval. There can
be no assurance that such trials will accrue sufficient patients,
be conducted with sufficient quality, in a timely manner, have a
successful outcome, or that regulatory approval will be obtained.
In addition, we are reliant on external manufacturing, and any interruption
or delay in drug supply could adversely affect the development program.
More detailed information regarding factors that may cause actual
results to differ materially from the results expressed or implied
by statements in this press release may be found in Telik’s
periodic filings with the Securities and Exchange Commission. Telik
assumes no obligation to update any information in this press release.
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Contact:
Carol DeGuzman
Senior Director, Corporate Communications
Telik, Inc.
Tel 650-845-7728
Email cdeguzman@telik.com
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